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OBJECTIVE: To analyze the clinical features,diagnosis and treatment plan and clinical outcomes of pregnancy with ovarian cancer.METHODS: Retrospectively analyze the clinical data of 11 pregnant women with ovarian cancer admitted to five hospitals in Dalian from October 2005 to December 2018.RESULTS: The incidence of pregnancy with ovarian cancer was 0.05‰（11/241 770).Among 11 cases of pregnancy with ovarian cancer,7 cases were primary malignant ovarian tumors,of which there was one case without staging during operation,5 cases of stageⅠ,and 1 case of stage ⅢC.The except stage Ⅲ C patient gave up pregnancy,while the other 6 patients chose to terminate pregnancy on the premise of ensuring the survival of the fetus.Four cases were ovarian metastatic tumors,of which 3 were surgically treated,and all4 patients required to retain the fetus and abandon the treatment for malignant tumors.There were 9 neonates,including 4 premature infants,of whom,1 case died 5 minutes after birth and the remaining 8 neonates were healthy.CONCLUSION: The pregnancy with ovarian cancer lacks typical clinical symptoms;the combination of multiple auxiliary examinations is of great significance in the diagnosis of diseases.Diagnosis and staging can be determined according to the intraoperative and postoperative pathological results.We should be alert to metastatic tumors.The individualized treatment plan of the disease should be based on the pregnancy status,the type of tumor pathology and the stage of the tumor,the wishes of the patient and the family.
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<p><b>OBJECTIVE</b>To evaluate the effect of different combined immunoprophylaxis delivery modes on mother to infant transmission of hepatitis B virus (HBV).</p><p><b>METHODS</b>Six hundred and ninety-six relevant literatures were collected by systematic literature search. Meta-analysis was applied to seven selected literatures that met the criteria and to assess the influence on the infant HBV transmission via different delivery patterns by infants combined immunoprophylaxis.</p><p><b>RESULTS</b>A total of 1435 cases from seven studies which met the criteria were included. The positive rate of HBV was 7.34% (61/831) among the 831 infants in the vaginal delivery group and 4.80% (29/604) among the 604 infants in the caesarean section group. There was no statistically difference between the two groups (OR = 0.70, 95%CI: 0.45 - 1.11, Z = 1.52, P = 0.13).</p><p><b>CONCLUSION</b>There was no significant effect of delivery modes on infant infectious rate of HBV by infants' passive and active immunization.</p>
Subject(s)
Female , Humans , Infant , Pregnancy , Delivery, Obstetric , Methods , Hepatitis B , Hepatitis B Vaccines , Therapeutic Uses , Hepatitis B virus , Immunization , Infectious Disease Transmission, VerticalABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of ulinastatin on renal function and ultrastructure changes after renal ischemia-reperfusion in rats.</p><p><b>METHODS</b>Acute ischemic renal injury model was established (45 min of bilateral renal ischemia and reperfusion for 24 h). Thirty Male SD rats were randomly divided into 3 groups: sham operation group (control group or group C, without renal ischemia), renal ischemia-reperfusion group (ischemia-reperfusion group or group I, without ulinastatin), renal ischemia-reperfusion and ulinastatin intravenous injection group (ulinastatin group or group U). BUN level, serum creatinine values and renal ultrastructure were measured.</p><p><b>RESULTS</b>Serum creatinine (167 +/- 39) micromol/L and BUN concentration (21 +/- 7) mmol/L in group I were significantly higher than those in group U: serum creatinine (116 +/- 13) micromol/L and BUN concentration (14.1 +/- 2.6) mmol/L (P < 0.05). The renal ultrastructure was greatly injured in group I, meanwhile, it was obviously ameliorated in group U.</p><p><b>CONCLUSION</b>Ulinastatin greatly improved renal function and provides remarkable protection on renal ultrastructure after ischemia-reperfusion of kidney in rats.</p>